Metabolic and Hematologic Genetic Diseases

ABCC8 is the top known cause of congenital hyperinsulinism. See what guidelines and recent studies say about inheritance, 23andMe results, and new drugs.

Turning red after one drink is a sign of the ALDH2*2 variant. See what large studies show about acetaldehyde, cancer risk, testing, and drinking less.

HDL cholesterol genetics explained: twin and gene studies, why HDL-raising drugs failed in large trials, and what very high HDL may mean for health.

Most inherited high LDL comes from thousands of small gene effects, not one gene. See what a polygenic LDL report means, how it differs from FH, and next steps.

Gestational diabetes is partly genetic. A 2024 study of 143,000 women found two kinds of genetic risk, but every pregnancy still needs the glucose test.

Are kidney stones genetic? Twin, family and gene studies in plain English, what a 23andMe score means, warning signs, and prevention backed by trials.

Most high triglycerides come from many small gene effects plus lifestyle, not one gene. Learn the numbers, pancreatitis risk, testing and new drugs.

A study of 1,028,980 adults mapped blood pressure genetics in detail. Here is what a polygenic risk report can tell you, and what only a cuff can.

Polygenic gallstone risk, explained: what the 2025 71,384-case study found, why an ultrasound beats a DNA kit, and what the odds mean out of 100.

A genetic risk score for coronary artery disease shifts your odds, not your fate. Here is what the research shows, in plain out-of-100 numbers.