Hereditary Cancer

A high prostate cancer risk score is not a diagnosis. Studies of 450+ gene variants show what it means in real numbers, by ancestry, and for PSA screening.

Gene studies of 300,000+ people show BCC and SCC risk is polygenic. Learn what a 23andMe score adds to sun, skin type and family history, and what to do next.

Most breast cancer happens without a BRCA variant. Here is what a polygenic score of thousands of common variants really measures, in people out of 100.

A 23andMe "increased likelihood" colorectal cancer result isn't a diagnosis. What a polygenic score means, and how it differs from Lynch syndrome testing.

Melanoma risk comes in two layers — a rare high-risk gene and a common polygenic score. Here is what a 23andMe "Skin Cancer" result really means.

A study of 592,158 men put HOXB13 G84E at a hazard ratio of 3.17. Here is what that means in absolute numbers, and what it means for screening, family and insurance.

A BLM carrier flag is not Bloom syndrome: the inheritance math, the registry cancer numbers, testing routes in the US and Canada, and what GINA leaves out.

A FANCC carrier flag is not a diagnosis. A research-grounded guide to Fanconi anemia group C: per-pregnancy odds, testing, cancer risk, and 2026 treatments.

MUTYH-associated polyposis is an inherited colon-cancer syndrome. Learn what biallelic vs monoallelic risk really means, how a 23andMe result differs from clinical testing, and your GINA rights.

A BRCA1 or BRCA2 mutation raises cancer risk well above average, but it is not a guarantee. Here is what the research shows, in plain numbers.