Metabolic and Hematologic Genetic Diseases

G6PD deficiency is the most common human enzyme defect, affecting an estimated 400 million people. This research-based guide explains X-linked inheritance, testing, drug safety, and US/Canada privacy law.

A '23andMe HLA-DQ2/DQ8' flag sounds like a celiac diagnosis. Research shows the opposite: about 30-35% of people carry it, only ~3% of carriers ever develop celiac, and its real value is ruling the disease OUT.

An 'FH' flag or a stubbornly high LDL sounds like a verdict of early heart disease. Research shows the real danger is being missed — and that FH is one of the most treatable inherited risks.

A 'C282Y homozygous' result on a DNA test sounds alarming, but research shows most homozygotes never develop iron-overload disease. Here is what it means and what to do.